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KMID : 1007520070160050843
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Food Science and Biotechnology
2007 Volume.16 No. 5 p.843 ~ p.847
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Potential Probiotic Properties of Lactococcus Lactis NK34 Isolated from Jeotgal
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Lee Na-Kyoung
Noh Ji-Eun
Choi Gui-Hun
Park Eun-Ju
Chang Hyo-Ihl
Yun Cheol-Won
Kim Seung-Wook
Kang Chang-Won
Yoon Yoh-Chang
Paik Hyun-Dong
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Abstract
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Strain NK34 was characterized for probiotic use. Strain NK34 was named Lactococcus lactis NK34 based on API 50 CHL kit results and 16S rDNA sequencing. L. lactis NK34 was highly resistant to artificial gastric juice (pH 2.5) and artificial bile acid. Based on results from the API ZYM kit, 4 enzymes were produced. L. lactis NK34 was resistant to all antibiotics tested except for 10 μg/mL roxithromycin and 10 μg/mL erythromycin. The cholesterol-lowering effect of L. lactis NK34 was about 46.9%. Concentrations of interleukin (IL)-1α in the 20× concentrated supernatant of L. lactis NK34 was about 361 pg/mL. L. lactis NK34 was also found to inhibit the growth of colon cancer cells due to MNNG-induced DNA damage. These results demonstrate the potential of L. lactis NK34 as a health-promoting probiotic.
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KEYWORD
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Lactococcus Lactis, jeotgal, probiotics, cholesterol-Lowering activity, immunolstimulating activity, DNA damage
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